Hypoxia enhances H(2)O(2)-mediated upregulation of hepcidin: Evidence for NOX4-mediated iron regulation

The exact regulation of the liver-secreted peptide hepcidin, the key regulator of systemic iron homeostasis, is still poorly understood. It is potently induced by iron, inflammation, cytokines or H(2)O(2) but conflicting results have been reported on hypoxia. In our current study, we first show that...

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Detalles Bibliográficos
Autores principales: Silva, Inês, Rausch, Vanessa, Peccerella, Teresa, Millonig, Gunda, Seitz, Helmut-Karl, Mueller, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832675/
https://www.ncbi.nlm.nih.gov/pubmed/29459227
http://dx.doi.org/10.1016/j.redox.2018.02.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832675/
https://www.ncbi.nlm.nih.gov/pubmed/29459227
http://dx.doi.org/10.1016/j.redox.2018.02.005

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