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Hypoxia enhances H(2)O(2)-mediated upregulation of hepcidin: Evidence for NOX4-mediated iron regulation
The exact regulation of the liver-secreted peptide hepcidin, the key regulator of systemic iron homeostasis, is still poorly understood. It is potently induced by iron, inflammation, cytokines or H(2)O(2) but conflicting results have been reported on hypoxia. In our current study, we first show that...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832675/ https://www.ncbi.nlm.nih.gov/pubmed/29459227 http://dx.doi.org/10.1016/j.redox.2018.02.005 |