Cargando…
De novo adipocyte differentiation from Pdgfrβ(+) preadipocytes protects against pathologic visceral adipose expansion in obesity
Pathologic expansion of white adipose tissue (WAT) in obesity is characterized by adipocyte hypertrophy, inflammation, and fibrosis; however, factors triggering this maladaptive remodeling are largely unknown. Here, we test the hypothesis that the potential to recruit new adipocytes from Pdgfrβ(+) p...
Autores principales: | Shao, Mengle, Vishvanath, Lavanya, Busbuso, Napoleon C., Hepler, Chelsea, Shan, Bo, Sharma, Ankit X., Chen, Shiuhwei, Yu, Xinxin, An, Yu A., Zhu, Yi, Holland, William L., Gupta, Rana K. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832777/ https://www.ncbi.nlm.nih.gov/pubmed/29497032 http://dx.doi.org/10.1038/s41467-018-03196-x |
Ejemplares similares
-
Fetal development of subcutaneous white adipose tissue is dependent on Zfp423
por: Shao, Mengle, et al.
Publicado: (2016) -
Directing visceral white adipocyte precursors to a thermogenic adipocyte fate improves insulin sensitivity in obese mice
por: Hepler, Chelsea, et al.
Publicado: (2017) -
Sorting out adipocyte precursors and their role in physiology and disease
por: Hepler, Chelsea, et al.
Publicado: (2017) -
Cold-responsive adipocyte progenitors couple adrenergic signaling to immune cell activation to promote beige adipocyte accrual
por: Shan, Bo, et al.
Publicado: (2021) -
Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice
por: Hepler, Chelsea, et al.
Publicado: (2018)