Large XPF-dependent deletions following misrepair of a DNA double strand break are prevented by the RNA:DNA helicase Senataxin

Deletions and chromosome re-arrangements are common features of cancer cells. We have established a new two-component system reporting on epigenetic silencing or deletion of an actively transcribed gene adjacent to a double-strand break (DSB). Unexpectedly, we find that a targeted DSB results in a m...

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Detalles Bibliográficos
Autores principales: Brustel, Julien, Kozik, Zuzanna, Gromak, Natalia, Savic, Velibor, Sweet, Steve M. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832799/
https://www.ncbi.nlm.nih.gov/pubmed/29497062
http://dx.doi.org/10.1038/s41598-018-21806-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832799/
https://www.ncbi.nlm.nih.gov/pubmed/29497062
http://dx.doi.org/10.1038/s41598-018-21806-y

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