Rapid measurement of inhibitor binding kinetics by isothermal titration calorimetry

Although drug development typically focuses on binding thermodynamics, recent studies suggest that kinetic properties can strongly impact a drug candidate’s efficacy. Robust techniques for measuring inhibitor association and dissociation rates are therefore essential. To address this need, we have d...

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Detalles Bibliográficos
Autores principales: Di Trani, Justin M., De Cesco, Stephane, O’Leary, Rebecca, Plescia, Jessica, do Nascimento, Claudia Jorge, Moitessier, Nicolas, Mittermaier, Anthony K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832847/
https://www.ncbi.nlm.nih.gov/pubmed/29497037
http://dx.doi.org/10.1038/s41467-018-03263-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832847/
https://www.ncbi.nlm.nih.gov/pubmed/29497037
http://dx.doi.org/10.1038/s41467-018-03263-3

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