A Highly Sensitive Detection System based on Proximity-dependent Hybridization with Computer-aided Affinity Maturation of a scFv Antibody

The hepatitis B virus (HBV) infection is a critical health problem worldwide, and HBV preS1 is an important biomarker for monitoring HBV infection. Previously, we found that a murine monoclonal antibody, mAb-D8, targets the preS1 (aa91-107) fragment of HBV. To improve its performance, we prepared th...

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Detalles Bibliográficos
Autores principales: Wang, Zhiheng, Li, Yan, Liang, Wenbin, Zheng, Junsong, Li, Shuhui, Hu, Chuanmin, Chen, An
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832849/
https://www.ncbi.nlm.nih.gov/pubmed/29497069
http://dx.doi.org/10.1038/s41598-018-22111-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832849/
https://www.ncbi.nlm.nih.gov/pubmed/29497069
http://dx.doi.org/10.1038/s41598-018-22111-4

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