A CRISPR Cas9-based gene drive platform for genetic interaction analysis in Candida albicans

Candida albicans is the leading cause of fungal infections; yet, complex genetic interaction analysis remains cumbersome in this diploid pathogen. Here, we developed a CRISPR-Cas9-based ‘gene drive array’ (GDA) platform to facilitate efficient genetic analysis in C. albicans. In our system, a modifi...

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Detalles Bibliográficos
Autores principales: Shapiro, Rebecca S., Chavez, Alejandro, Porter, Caroline B. M., Hamblin, Meagan, Kaas, Christian S., DiCarlo, James E., Zeng, Guisheng, Xu, Xiaoli, Revtovich, Alexey V., Kirienko, Natalia V., Wang, Yue, Church, George M., Collins, James J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832965/
https://www.ncbi.nlm.nih.gov/pubmed/29062088
http://dx.doi.org/10.1038/s41564-017-0043-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832965/
https://www.ncbi.nlm.nih.gov/pubmed/29062088
http://dx.doi.org/10.1038/s41564-017-0043-0

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