MEKK1, JNK, and SMAD3 mediate CXCL12-stimulated connective tissue growth factor expression in human lung fibroblasts

BACKGROUND: In idiopathic pulmonary fibrosis, the interaction of CXCL12 and CXC receptor 4 (CXCR4) plays a critical role in lung fibrosis. Connective tissue growth factor (CTGF) overexpression underlies the development of pulmonary fibrosis. Our previous report showed that the Rac1-dependent extrace...

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Detalles Bibliográficos
Autores principales: Lin, Chien-Huang, Shih, Chung-Huang, Lin, Yu-Chang, Yang, You-Lan, Chen, Bing-Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833071/
https://www.ncbi.nlm.nih.gov/pubmed/29499695
http://dx.doi.org/10.1186/s12929-018-0421-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833071/
https://www.ncbi.nlm.nih.gov/pubmed/29499695
http://dx.doi.org/10.1186/s12929-018-0421-9

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