Integrating linear optimization with structural modeling to increase HIV neutralization breadth

Computational protein design has been successful in modeling fixed backbone proteins in a single conformation. However, when modeling large ensembles of flexible proteins, current methods in protein design have been insufficient. Large barriers in the energy landscape are difficult to traverse while...

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Detalles Bibliográficos
Autores principales: Sevy, Alexander M., Panda, Swetasudha, Crowe, James E., Meiler, Jens, Vorobeychik, Yevgeniy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833279/
https://www.ncbi.nlm.nih.gov/pubmed/29451898
http://dx.doi.org/10.1371/journal.pcbi.1005999

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833279/
https://www.ncbi.nlm.nih.gov/pubmed/29451898
http://dx.doi.org/10.1371/journal.pcbi.1005999

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