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Integrating linear optimization with structural modeling to increase HIV neutralization breadth
Computational protein design has been successful in modeling fixed backbone proteins in a single conformation. However, when modeling large ensembles of flexible proteins, current methods in protein design have been insufficient. Large barriers in the energy landscape are difficult to traverse while...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833279/ https://www.ncbi.nlm.nih.gov/pubmed/29451898 http://dx.doi.org/10.1371/journal.pcbi.1005999 |