Loss of the Drosophilam-AAA mitochondrial protease paraplegin results in mitochondrial dysfunction, shortened lifespan, and neuronal and muscular degeneration

The progressive accumulation of dysfunctional mitochondria is implicated in aging and in common diseases of the elderly. To oppose this occurrence, organisms employ a variety of strategies, including the selective degradation of oxidatively damaged and misfolded mitochondrial proteins. Genetic studi...

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Detalles Bibliográficos
Autores principales: Pareek, Gautam, Thomas, Ruth E., Pallanck, Leo J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833341/
https://www.ncbi.nlm.nih.gov/pubmed/29467464
http://dx.doi.org/10.1038/s41419-018-0365-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833341/
https://www.ncbi.nlm.nih.gov/pubmed/29467464
http://dx.doi.org/10.1038/s41419-018-0365-8

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