Downregulated Nuclear Factor E2-Related Factor 2 (Nrf2) Aggravates Cognitive Impairments via Neuroinflammation and Synaptic Plasticity in the Senescence-Accelerated Mouse Prone 8 (SAMP8) Mouse: A Model of Accelerated Senescence

BACKGROUND: We observed the effects of nuclear factor E2-related factor 2 (Nrf2) downregulation via intrahippocampal injection of a lentiviral vector on cognition in senescence-accelerated mouse prone 8 (SAMP8) to investigate the role of the (Nrf2)/antioxidant response element (ARE) pathway in age-r...

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Detalles Bibliográficos
Autores principales: Ren, Hui Ling, Lv, Chao Nan, Xing, Ying, Geng, Yuan, Zhang, Feng, Bu, Wei, Wang, Ming Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2018
Materias:
Animal Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833362/
https://www.ncbi.nlm.nih.gov/pubmed/29474348
http://dx.doi.org/10.12659/MSM.908954

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833362/
https://www.ncbi.nlm.nih.gov/pubmed/29474348
http://dx.doi.org/10.12659/MSM.908954

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