Norisoboldine, a natural AhR agonist, promotes Treg differentiation and attenuates colitis via targeting glycolysis and subsequent NAD(+)/SIRT1/SUV39H1/H3K9me3 signaling pathway

Norisoboldine (NOR), a natural aryl hydrocarbon receptor (AhR) agonist, has been demonstrated to attenuate ulcerative colitis (UC) and induce the generation of Treg cells. Under UC condition, hypoxia widely exists in colonic mucosa, and secondary changes of microRNAs (miRs) expressions and glycolysi...

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Detalles Bibliográficos
Autores principales: Lv, Qi, Wang, Kai, Qiao, Simiao, Yang, Ling, Xin, Yirong, Dai, Yue, Wei, Zhifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833367/
https://www.ncbi.nlm.nih.gov/pubmed/29449535
http://dx.doi.org/10.1038/s41419-018-0297-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833367/
https://www.ncbi.nlm.nih.gov/pubmed/29449535
http://dx.doi.org/10.1038/s41419-018-0297-3

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