Covalent ISG15 conjugation to CHIP promotes its ubiquitin E3 ligase activity and inhibits lung cancer cell growth in response to type I interferon

The carboxyl terminus of Hsp70-interacting protein (CHIP) acts as a ubiquitin E3 ligase and a link between the chaperones Hsp70/90 and the proteasome system, playing a vital role in maintaining protein homeostasis. CHIP regulates a number of proteins involved in a myriad of physiological and patholo...

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Detalles Bibliográficos
Autores principales: Yoo, Lang, Yoon, A-Rum, Yun, Chae-Ok, Chung, Kwang Chul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833375/
https://www.ncbi.nlm.nih.gov/pubmed/29367604
http://dx.doi.org/10.1038/s41419-017-0138-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833375/
https://www.ncbi.nlm.nih.gov/pubmed/29367604
http://dx.doi.org/10.1038/s41419-017-0138-9

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