Inhibition of p53 prevents diabetic cardiomyopathy by preventing early-stage apoptosis and cell senescence, reduced glycolysis, and impaired angiogenesis

Elevated tumor suppressor p53 expression has been associated with heart diseases, including the diabetic heart. However, its precise role in the pathogenesis of diabetic cardiomyopathy (DCM) remains unclear. We hypothesized that the development of DCM is attributed to up-regulated p53-mediated both...

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Detalles Bibliográficos
Autores principales: Gu, Junlian, Wang, Shudong, Guo, Hua, Tan, Yi, Liang, Yaqin, Feng, Anyun, Liu, Qiuju, Damodaran, Chendil, Zhang, Zhiguo, Keller, Bradley B., Zhang, Chi, Cai, Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833384/
https://www.ncbi.nlm.nih.gov/pubmed/29362483
http://dx.doi.org/10.1038/s41419-017-0093-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833384/
https://www.ncbi.nlm.nih.gov/pubmed/29362483
http://dx.doi.org/10.1038/s41419-017-0093-5

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