Sphingolipid de novo biosynthesis is essential for intestine cell survival and barrier function

Serine palmitoyltransferase (SPT) is the rate-limiting enzyme for sphingolipid biosynthesis. SPT has two major subunits, SPTLC1 and SPTLC2. We previously found that liver Sptlc2 deficiency in early life impairs the development of adherens junctions. Here, we investigated the role of Sptlc2 deficienc...

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Detalles Bibliográficos
Autores principales: Li, Zhiqiang, Kabir, Inamul, Tietelman, Gladys, Huan, Chongmin, Fan, Jianglin, Worgall, Tilla, Jiang, Xian-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833386/
https://www.ncbi.nlm.nih.gov/pubmed/29415989
http://dx.doi.org/10.1038/s41419-017-0214-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833386/
https://www.ncbi.nlm.nih.gov/pubmed/29415989
http://dx.doi.org/10.1038/s41419-017-0214-1

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