Inactivation of ribosomal protein S27-like confers radiosensitivity via the Mdm2-p53 and Mdm2–MRN–ATM axes

RPS27L (ribosomal protein S27-like) is an evolutionarily conserved ribosomal protein and a direct p53 target. We recently reported that Rps27l disruption triggers ribosomal stress to induce p53, causing postnatal death, which can be rescued by Trp53(+/−). Whether and how Rps27l modulates radiosensit...

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Detalles Bibliográficos
Autores principales: Zhao, Yongchao, Tan, Mingjia, Liu, Xia, Xiong, Xiufang, Sun, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833388/
https://www.ncbi.nlm.nih.gov/pubmed/29396424
http://dx.doi.org/10.1038/s41419-017-0192-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833388/
https://www.ncbi.nlm.nih.gov/pubmed/29396424
http://dx.doi.org/10.1038/s41419-017-0192-3

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