Efficacy of the highly selective focal adhesion kinase inhibitor BI 853520 in adenocarcinoma xenograft models is linked to a mesenchymal tumor phenotype

Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, has attracted interest as a target for pharmacological intervention in malignant diseases. Here, we describe BI 853520, a novel ATP-competitive inhibitor distinguished by high potency and selectivity. In vitro, the compound inhibits FAK au...

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Detalles Bibliográficos
Autores principales: Hirt, Ulrich A., Waizenegger, Irene C., Schweifer, Norbert, Haslinger, Christian, Gerlach, Daniel, Braunger, Jürgen, Weyer-Czernilofsky, Ulrike, Stadtmüller, Heinz, Sapountzis, Ioannis, Bader, Gerd, Zoephel, Andreas, Bister, Bojan, Baum, Anke, Quant, Jens, Kraut, Norbert, Garin-Chesa, Pilar, Adolf, Günther R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833389/
https://www.ncbi.nlm.nih.gov/pubmed/29472531
http://dx.doi.org/10.1038/s41389-018-0032-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833389/
https://www.ncbi.nlm.nih.gov/pubmed/29472531
http://dx.doi.org/10.1038/s41389-018-0032-z

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