MicroRNA-146a-5p attenuates irradiation-induced and LPS-induced hepatic stellate cell activation and hepatocyte apoptosis through inhibition of TLR4 pathway

Elevated toll-like receptor 4 (TLR4) expression is associated with a high risk of radiation-induced liver disease (RILD). MicroRNA (miR)-146a-5p is a key regulator of lipopolysaccharide (LPS)/TLR4 signaling, but its role in modulation of RILD remains unclear. Here, we found that irradiation and LPS...

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Detalles Bibliográficos
Autores principales: Chen, Yuhan, Wu, Zhifeng, Yuan, Baoying, Dong, Yinying, Zhang, Li, Zeng, Zhaochong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833436/
https://www.ncbi.nlm.nih.gov/pubmed/29348414
http://dx.doi.org/10.1038/s41419-017-0038-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833436/
https://www.ncbi.nlm.nih.gov/pubmed/29348414
http://dx.doi.org/10.1038/s41419-017-0038-z

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