Mitochondrial glutamine metabolism via GOT2 supports pancreatic cancer growth through senescence inhibition

Cellular senescence, which leads to a cell cycle arrest of damaged or dysfunctional cells, is an important mechanism to restrain the malignant progression of cancer cells. Because metabolic changes underlie many cell-fate decisions, it has been suggested that cell metabolism might play key roles in...

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Detalles Bibliográficos
Autores principales: Yang, Seungyeon, Hwang, Sunsook, Kim, Minjoong, Seo, Sung Bin, Lee, Jeong-Hwa, Jeong, Seung Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833441/
https://www.ncbi.nlm.nih.gov/pubmed/29352139
http://dx.doi.org/10.1038/s41419-017-0089-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833441/
https://www.ncbi.nlm.nih.gov/pubmed/29352139
http://dx.doi.org/10.1038/s41419-017-0089-1

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