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Mitochondrial glutamine metabolism via GOT2 supports pancreatic cancer growth through senescence inhibition
Cellular senescence, which leads to a cell cycle arrest of damaged or dysfunctional cells, is an important mechanism to restrain the malignant progression of cancer cells. Because metabolic changes underlie many cell-fate decisions, it has been suggested that cell metabolism might play key roles in...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833441/ https://www.ncbi.nlm.nih.gov/pubmed/29352139 http://dx.doi.org/10.1038/s41419-017-0089-1 |