PI3K/mTOR inhibition promotes the regression of experimental vascular malformations driven by PIK3CA-activating mutations

Somatic activating mutations within the PIK3CA gene have been recently detected in sporadic lymphatic and venous malformations, and in vascular malformations (VM) associated to overgrowth syndromes, such as CLOVES and Klippel–Trenaunay syndrome. Although VM are often limited to specific tissue areas...

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Detalles Bibliográficos
Autores principales: di Blasio, Laura, Puliafito, Alberto, Gagliardi, Paolo Armando, Comunanza, Valentina, Somale, Desiana, Chiaverina, Giulia, Bussolino, Federico, Primo, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833448/
https://www.ncbi.nlm.nih.gov/pubmed/29352118
http://dx.doi.org/10.1038/s41419-017-0064-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833448/
https://www.ncbi.nlm.nih.gov/pubmed/29352118
http://dx.doi.org/10.1038/s41419-017-0064-x

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