The MiR-135b–BMAL1–YY1 loop disturbs pancreatic clockwork to promote tumourigenesis and chemoresistance

Circadian disruption has been implicated in tumour development, but the underlying mechanism remains unclear. Here, we show that the molecular clockwork within malignant human pancreatic epithelium is disrupted and that this disruption is mediated by miR-135b-induced BMAL1 repression. miR-135b direc...

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Detalles Bibliográficos
Autores principales: Jiang, Weiliang, Zhao, Senlin, Shen, Jia, Guo, Lihong, Sun, Yi, Zhu, Yuntian, Ma, Zhixiong, Zhang, Xin, Hu, Yangyang, Xiao, Wenqin, Li, Kai, Li, Sisi, Zhou, Li, Huang, Li, Lu, Zhanjun, Feng, Yun, Xiao, Junhua, Zhang, Eric Erquan, Yang, Lijuan, Wan, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833454/
https://www.ncbi.nlm.nih.gov/pubmed/29396463
http://dx.doi.org/10.1038/s41419-017-0233-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833454/
https://www.ncbi.nlm.nih.gov/pubmed/29396463
http://dx.doi.org/10.1038/s41419-017-0233-y

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