Effect of mitochondrial uncouplers niclosamide ethanolamine (NEN) and oxyclozanide on hepatic metastasis of colon cancer

Metabolism of cancer cells is characterized by aerobic glycolysis, or the Warburg effect. Aerobic glycolysis reduces pyruvate flux into mitochondria, preventing a complete oxidation of glucose and shunting glucose to anabolic pathways essential for cell proliferation. Here we tested a new strategy,...

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Detalles Bibliográficos
Autores principales: Alasadi, Amer, Chen, Michael, Swapna, G. V. T., Tao, Hanlin, Guo, Jingjing, Collantes, Juan, Fadhil, Noor, Montelione, Gaetano T., Jin, Shengkan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833462/
https://www.ncbi.nlm.nih.gov/pubmed/29440715
http://dx.doi.org/10.1038/s41419-017-0092-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833462/
https://www.ncbi.nlm.nih.gov/pubmed/29440715
http://dx.doi.org/10.1038/s41419-017-0092-6

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