Dual suppression of inner and outer mitochondrial membrane functions augments apoptotic responses to oncogenic MAPK inhibition

Mitogen-activated protein kinase (MAPK) pathway inhibitors show promise in treating melanoma, but are unsuccessful in achieving long-term remission. Concordant with clinical data, BRAF(V600E) melanoma cells eliminate glycolysis upon inhibition of BRAF(V600E) or MEK with the targeted therapies Vemura...

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Detalles Bibliográficos
Autores principales: Serasinghe, Madhavika N., Gelles, Jesse D., Li, Kent, Zhao, Lauren, Abbate, Franco, Syku, Marie, Mohammed, Jarvier N., Badal, Brateil, Rangel, Cuahutlehuanitzin A., Hoehn, Kyle L., Celebi, Julide Tok, Chipuk, Jerry Edward
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833689/
https://www.ncbi.nlm.nih.gov/pubmed/29348439
http://dx.doi.org/10.1038/s41419-017-0044-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833689/
https://www.ncbi.nlm.nih.gov/pubmed/29348439
http://dx.doi.org/10.1038/s41419-017-0044-1

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