RIPK1-dependent cell death: a novel target of the Aurora kinase inhibitor Tozasertib (VX-680)

The Aurora kinase family (Aurora A, B and C) are crucial regulators of several mitotic events, including cytokinesis. Increased expression of these kinases is associated with tumorigenesis and several compounds targeting Aurora kinase are under evaluation in clinical trials (a.o. AT9283, AZD1152, Da...

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Detalles Bibliográficos
Autores principales: Martens, Sofie, Goossens, Vera, Devisscher, Lars, Hofmans, Sam, Claeys, Polien, Vuylsteke, Marnik, Takahashi, Nozomi, Augustyns, Koen, Vandenabeele, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833749/
https://www.ncbi.nlm.nih.gov/pubmed/29434255
http://dx.doi.org/10.1038/s41419-017-0245-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833749/
https://www.ncbi.nlm.nih.gov/pubmed/29434255
http://dx.doi.org/10.1038/s41419-017-0245-7

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