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RIPK1-dependent cell death: a novel target of the Aurora kinase inhibitor Tozasertib (VX-680)
The Aurora kinase family (Aurora A, B and C) are crucial regulators of several mitotic events, including cytokinesis. Increased expression of these kinases is associated with tumorigenesis and several compounds targeting Aurora kinase are under evaluation in clinical trials (a.o. AT9283, AZD1152, Da...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833749/ https://www.ncbi.nlm.nih.gov/pubmed/29434255 http://dx.doi.org/10.1038/s41419-017-0245-7 |