A novel ruthenium complex with xanthoxylin induces S-phase arrest and causes ERK1/2-mediated apoptosis in HepG2 cells through a p53-independent pathway

Ruthenium-based compounds have gained great interest due to their potent cytotoxicity in cancer cells; however, much of their potential applications remain unexplored. In this paper, we report the synthesis of a novel ruthenium complex with xanthoxylin (RCX) and the investigation of its cellular and...

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Detalles Bibliográficos
Autores principales: de Carvalho, Nanashara C., Neves, Sara P., Dias, Rosane B., Valverde, Ludmila de F., Sales, Caroline B. S., Rocha, Clarissa A. G., Soares, Milena B. P., dos Santos, Edjane R., Oliveira, Regina M. M., Carlos, Rose M., Nogueira, Paulo C. L., Bezerra, Daniel P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833756/
https://www.ncbi.nlm.nih.gov/pubmed/29362398
http://dx.doi.org/10.1038/s41419-017-0104-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833756/
https://www.ncbi.nlm.nih.gov/pubmed/29362398
http://dx.doi.org/10.1038/s41419-017-0104-6

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