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A novel ruthenium complex with xanthoxylin induces S-phase arrest and causes ERK1/2-mediated apoptosis in HepG2 cells through a p53-independent pathway
Ruthenium-based compounds have gained great interest due to their potent cytotoxicity in cancer cells; however, much of their potential applications remain unexplored. In this paper, we report the synthesis of a novel ruthenium complex with xanthoxylin (RCX) and the investigation of its cellular and...
Autores principales: | de Carvalho, Nanashara C., Neves, Sara P., Dias, Rosane B., Valverde, Ludmila de F., Sales, Caroline B. S., Rocha, Clarissa A. G., Soares, Milena B. P., dos Santos, Edjane R., Oliveira, Regina M. M., Carlos, Rose M., Nogueira, Paulo C. L., Bezerra, Daniel P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833756/ https://www.ncbi.nlm.nih.gov/pubmed/29362398 http://dx.doi.org/10.1038/s41419-017-0104-6 |
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