Targeted reduction of the EGFR protein, but not inhibition of its kinase activity, induces mitophagy and death of cancer cells through activation of mTORC2 and Akt

The oncogenic epidermal growth factor receptor (EGFR) is commonly overexpressed in solid cancers. The tyrosine kinase activity of EGFR has been a major therapeutic target for cancer; however, the efficacy of EGFR tyrosine kinase inhibitors to treat cancers has been challenged by innate and acquired...

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Detalles Bibliográficos
Autores principales: Katreddy, Rajasekhara Reddy, Bollu, Lakshmi Reddy, Su, Fei, Xian, Na, Srivastava, Shivangi, Thomas, Rintu, Dai, Yubing, Wu, Bing, Xu, Yunlu, Rea, Michael A., Briggs, James M., Zhang, Qingyuan, Lu, Xiongbin, Huang, Gangxiong, Weihua, Zhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833766/
https://www.ncbi.nlm.nih.gov/pubmed/29358623
http://dx.doi.org/10.1038/s41389-017-0021-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833766/
https://www.ncbi.nlm.nih.gov/pubmed/29358623
http://dx.doi.org/10.1038/s41389-017-0021-7

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