Co-inhibition of BET proteins and NF-κB as a potential therapy for colorectal cancer through synergistic inhibiting MYC and FOXM1 expressions

The bromodomain and extra-terminal domain inhibitors (BETi) are promising epigenetic drugs for the treatment of various cancers through suppression of oncogenic transcription factors. However, only a subset of colorectal cancer (CRC) cells response to BETi. We investigate additional agents that coul...

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Detalles Bibliográficos
Autores principales: Wu, Tingyu, Wang, Guanghui, Chen, Wei, Zhu, Zhehui, Liu, Yun, Huang, Zhenyu, Huang, Yuji, Du, Peng, Yang, Yili, Liu, Chen-Ying, Cui, Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833769/
https://www.ncbi.nlm.nih.gov/pubmed/29472532
http://dx.doi.org/10.1038/s41419-018-0354-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833769/
https://www.ncbi.nlm.nih.gov/pubmed/29472532
http://dx.doi.org/10.1038/s41419-018-0354-y

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