Downregulation of MCL-1 and upregulation of PUMA using mTOR inhibitors enhance antitumor efficacy of BH3 mimetics in triple-negative breast cancer

Triple-negative breast cancer (TNBC) shows a higher malignant and poorer clinical outcome compared with other breast cancer subtypes. Albeit that chemotherapy is the first choice for TNBC treatment, rapid emergence of chemoresistance and variability of chemotherapeutic responses in TNBC patients cal...

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Detalles Bibliográficos
Autores principales: Li, Haolong, Liu, Lei, Chang, Haocai, Zou, Zhengzhi, Xing, Da
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833778/
https://www.ncbi.nlm.nih.gov/pubmed/29374168
http://dx.doi.org/10.1038/s41419-017-0169-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833778/
https://www.ncbi.nlm.nih.gov/pubmed/29374168
http://dx.doi.org/10.1038/s41419-017-0169-2

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