Cargando…

Ethanol sensitizes hepatocytes for TGF-β-triggered apoptosis

Alcohol abuse is a global health problem causing a substantial fraction of chronic liver diseases. Abundant TGF-β—a potent pro-fibrogenic cytokine—leads to disease progression. Our aim was to elucidate the crosstalk of TGF-β and alcohol on hepatocytes. Primary murine hepatocytes were challenged with...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gaitantzi, Haristi, Meyer, Christoph, Rakoczy, Pia, Thomas, Maria, Wahl, Kristin, Wandrer, Franziska, Bantel, Heike, Alborzinia, Hamed, Wölfl, Stefan, Ehnert, Sabrina, Nüssler, Andreas, Bergheim, Ina, Ciuclan, Loredana, Ebert, Matthias, Breitkopf-Heinlein, Katja, Dooley, Steven
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833779/ https://www.ncbi.nlm.nih.gov/pubmed/29352207 http://dx.doi.org/10.1038/s41419-017-0071-y

Ejemplares similares

Identification of liver‐derived bone morphogenetic protein (BMP)‐9 as a potential new candidate for treatment of colorectal cancer
por: Cai, Chen, et al.
Publicado: (2021)

The right choice of antihypertensives protects primary human hepatocytes from ethanol- and recombinant human TGF-β(1)-induced cellular damage
por: Ehnert, Sabrina, et al.
Publicado: (2013)

Disruption of the Smad7 gene enhances CCI(4)-dependent liver damage and fibrogenesis in mice
por: Hamzavi, Jafar, et al.
Publicado: (2008)

Zonation of Nitrogen and Glucose Metabolism Gene Expression upon Acute Liver Damage in Mouse
por: Ghafoory, Shahrouz, et al.
Publicado: (2013)

Evolving Insights on Metabolism, Autophagy, and Epigenetics in Liver Myofibroblasts
por: Nwosu, Zeribe C., et al.
Publicado: (2016)

BMP-9 Modulates the Hepatic Responses to LPS
por: Gaitantzi, Haristi, et al.
Publicado: (2020)

Potential Roles of Bone Morphogenetic Protein (BMP)-9 in Human Liver Diseases
por: Herrera, Blanca, et al.
Publicado: (2014)

BH3-only protein expression determines hepatocellular carcinoma response to sorafenib-based treatment
por: Busche, Stephanie, et al.
Publicado: (2021)

Hepatic stellate cell-expressed endosialin balances fibrogenesis and hepatocyte proliferation during liver damage
por: Mogler, Carolin, et al.
Publicado: (2015)

EGF and HB-EGF enhance the proliferation of programmable cells of monocytic origin (PCMO) through activation of MEK/ERK signaling and improve differentiation of PCMO-derived hepatocyte-like cells
por: Hyder, Ayman, et al.
Publicado: (2012)

The drug-induced phenotypic landscape of colorectal cancer organoids
por: Betge, Johannes, et al.
Publicado: (2022)

Continuous multiparametric monitoring of cell metabolism in response to transient overexpression of the sirtuin deacetylase SIRT3
por: Dransfeld, Christian-Lars, et al.
Publicado: (2010)

In Vitro Generation of Functional Liver Organoid-Like Structures Using Adult Human Cells
por: Ramachandran, Sarada Devi, et al.
Publicado: (2015)

Autophagy alleviates amiodarone-induced hepatotoxicity
por: Wandrer, Franziska, et al.
Publicado: (2020)

Bio-impedance measurement allows displaying the early stages of neutrophil extracellular traps
por: Linnemann, Caren, et al.
Publicado: (2020)

A Standardized Collagen-Based Scaffold Improves Human Hepatocyte Shipment and Allows Metabolic Studies over 10 Days
por: Ruoß, Marc, et al.
Publicado: (2018)

Nuclear accumulation of CDH1 mRNA in hepatocellular carcinoma cells
por: Ghafoory, S, et al.
Publicado: (2015)

Osteolectin(+) stromal cells: Mechanical stimulation improves bone regeneration and supports bacterial clearance after fracture
por: Ehnert, Sabrina, et al.
Publicado: (2021)

Real-Time Monitoring of Cisplatin-Induced Cell Death
por: Alborzinia, Hamed, et al.
Publicado: (2011)

A TrxR inhibiting gold(I) NHC complex induces apoptosis through ASK1-p38-MAPK signaling in pancreatic cancer cells
por: Cheng, Xinlai, et al.
Publicado: (2014)

TNF-Receptor-1 inhibition reduces liver steatosis, hepatocellular injury and fibrosis in NAFLD mice
por: Wandrer, Franziska, et al.
Publicado: (2020)

Transforming growth factor β(1 )inhibits bone morphogenic protein (BMP)-2 and BMP-7 signaling via upregulation of Ski-related novel protein N (SnoN): possible mechanism for the failure of BMP therapy?
por: Ehnert, Sabrina, et al.
Publicado: (2012)

Caveolin-1 Impacts on TGF-β Regulation of Metabolic Gene Signatures in Hepatocytes
por: Han, Mei, et al.
Publicado: (2020)

Febrile-Range Hyperthermia Can Prevent Toxic Effects of Neutrophil Extracellular Traps on Mesenchymal Stem Cells
por: Linnemann, Caren, et al.
Publicado: (2022)

TGF-β(1) As Possible Link between Loss of Bone Mineral Density and Chronic Inflammation
por: Ehnert, Sabrina, et al.
Publicado: (2010)

Herbal Extracts of Ginseng and Maqui Berry Show Only Minimal Effects on an In Vitro Model of Early Fracture Repair of Smokers
por: Rinderknecht, Helen, et al.
Publicado: (2023)

Hepatic Osteodystrophy—Molecular Mechanisms Proposed to Favor Its Development
por: Ehnert, Sabrina, et al.
Publicado: (2019)

Effects of Prostaglandins on Ethanol Damage in Primary Cultured Rat Hepatocytes
por: Yang, Jin Mo, et al.
Publicado: (1998)

Mitophagy in hepatocytes: Types, initiators and role in adaptive ethanol metabolism☆
por: Lemasters, John J., et al.
Publicado: (2018)

Adenovirus-mediated overexpression of bone morphogenetic protein-9 promotes methionine choline deficiency-induced non-alcoholic steatohepatitis in non-obese mice
por: Li, Qi, et al.
Publicado: (2019)

Smoking Impairs Hematoma Formation and Dysregulates Angiogenesis as the First Steps of Fracture Healing
por: Rinderknecht, Helen, et al.
Publicado: (2022)

Induction of active demethylation and 5hmC formation by 5-azacytidine is TET2 dependent and suggests new treatment strategies against hepatocellular carcinoma
por: Sajadian, Sahar Olsadat, et al.
Publicado: (2015)

Intervertebral Disc Nucleus Repair: Hype or Hope?
por: Tendulkar, Gauri, et al.
Publicado: (2019)

Cholesterol Enhances the Toxic Effect of Ethanol and Acetaldehyde in Primary Mouse Hepatocytes
por: López-Islas, Anayelly, et al.
Publicado: (2016)

Golgi stress mediates redox imbalance and ferroptosis in human cells
por: Alborzinia, Hamed, et al.
Publicado: (2018)

In Vitro and in Vivo Models of Non-Alcoholic Fatty Liver Disease (NAFLD)
por: Kanuri, Giridhar, et al.
Publicado: (2013)

Use of in vitro bone models to screen for altered bone metabolism, osteopathies, and fracture healing: challenges of complex models
por: Ehnert, Sabrina, et al.
Publicado: (2020)

Establishment of an In Vitro Scab Model for Investigating Different Phases of Wound Healing
por: Liu, Chao, et al.
Publicado: (2022)

Superior antitumoral activity of dimerized targeted single-chain TRAIL fusion proteins under retention of tumor selectivity
por: Siegemund, M, et al.
Publicado: (2012)

Cell death in sepsis: a matter of how, when, and where
por: Bantel, Heike, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_96rnpoi5ri6mo0r6sar3muicb6