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Ubiquitin C decrement plays a pivotal role in replicative senescence of bone marrow mesenchymal stromal cells
Human bone marrow-mesenchymal stromal cells (hBM-MSCs) undergo cellular senescence during in vitro culture. In this study, we defined this replicative senescence as impaired proliferation, deterioration in representative cell characteristics, accumulated DNA damage, and decreased telomere length and...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833785/ https://www.ncbi.nlm.nih.gov/pubmed/29382826 http://dx.doi.org/10.1038/s41419-017-0032-5 |