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The histone methyltransferase DOT1L inhibits osteoclastogenesis and protects against osteoporosis
Osteoclasts are absorptive cells that play a critical role in homeostatic bone remodeling and pathological bone resorption. Emerging evidence suggests an important role of epigenetic regulation in osteoclastogenesis. In this study, we investigated the role of DOT1L, which regulates gene expression e...
Autores principales: | Gao, Yanpan, Ge, Wei |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833786/ https://www.ncbi.nlm.nih.gov/pubmed/29348610 http://dx.doi.org/10.1038/s41419-017-0040-5 |
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