Gambogenic acid inhibits fibroblast growth factor receptor signaling pathway in erlotinib-resistant non-small-cell lung cancer and suppresses patient-derived xenograft growth

Erlotinib resistance causes a high degree of lethality in non-small-cell lung cancer (NSCLC) patients. The high expression and activation of several receptor tyrosine kinases, such as JAK/STAT3, c-Met, and EGFR, play important roles in drug resistance. The development of tyrosine kinase inhibitors i...

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Detalles Bibliográficos
Autores principales: Xu, Linfeng, Meng, Xiaoxiao, Xu, Naihan, Fu, Wenwei, Tan, Hongsheng, Zhang, Li, Zhou, Qianjun, Qian, Jianan, Tu, Shiwei, Li, Xueting, Lao, Yuanzhi, Xu, Hongxi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833807/
https://www.ncbi.nlm.nih.gov/pubmed/29449529
http://dx.doi.org/10.1038/s41419-018-0314-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833807/
https://www.ncbi.nlm.nih.gov/pubmed/29449529
http://dx.doi.org/10.1038/s41419-018-0314-6

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