Pharmacological activation of autophagy favors the clearing of intracellular aggregates of misfolded prion protein peptide to prevent neuronal death

According to the “gain-of-toxicity mechanism”, neuronal loss during cerebral proteinopathies is caused by accumulation of aggregation-prone conformers of misfolded cellular proteins, although it is still debated which aggregation state actually corresponds to the neurotoxic entity. Autophagy, origin...

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Detalles Bibliográficos
Autores principales: Thellung, Stefano, Scoti, Beatrice, Corsaro, Alessandro, Villa, Valentina, Nizzari, Mario, Gagliani, Maria Cristina, Porcile, Carola, Russo, Claudio, Pagano, Aldo, Tacchetti, Carlo, Cortese, Katia, Florio, Tullio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833808/
https://www.ncbi.nlm.nih.gov/pubmed/29416016
http://dx.doi.org/10.1038/s41419-017-0252-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833808/
https://www.ncbi.nlm.nih.gov/pubmed/29416016
http://dx.doi.org/10.1038/s41419-017-0252-8

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