CAR-T cells: the long and winding road to solid tumors

Adoptive cell therapy of solid tumors with reprogrammed T cells can be considered the “next generation” of cancer hallmarks. CAR-T cells fail to be as effective as in liquid tumors for the inability to reach and survive in the microenvironment surrounding the neoplastic foci. The intricate net of cr...

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Autores principales: D’Aloia, Maria Michela, Zizzari, Ilaria Grazia, Sacchetti, Benedetto, Pierelli, Luca, Alimandi, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833816/
https://www.ncbi.nlm.nih.gov/pubmed/29449531
http://dx.doi.org/10.1038/s41419-018-0278-6
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author D’Aloia, Maria Michela
Zizzari, Ilaria Grazia
Sacchetti, Benedetto
Pierelli, Luca
Alimandi, Maurizio
author_facet D’Aloia, Maria Michela
Zizzari, Ilaria Grazia
Sacchetti, Benedetto
Pierelli, Luca
Alimandi, Maurizio
author_sort D’Aloia, Maria Michela
collection PubMed
description Adoptive cell therapy of solid tumors with reprogrammed T cells can be considered the “next generation” of cancer hallmarks. CAR-T cells fail to be as effective as in liquid tumors for the inability to reach and survive in the microenvironment surrounding the neoplastic foci. The intricate net of cross-interactions occurring between tumor components, stromal and immune cells leads to an ineffective anergic status favoring the evasion from the host’s defenses. Our goal is hereby to trace the road imposed by solid tumors to CAR-T cells, highlighting pitfalls and strategies to be developed and refined to possibly overcome these hurdles.
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spelling pubmed-58338162018-03-06 CAR-T cells: the long and winding road to solid tumors D’Aloia, Maria Michela Zizzari, Ilaria Grazia Sacchetti, Benedetto Pierelli, Luca Alimandi, Maurizio Cell Death Dis Review Article Adoptive cell therapy of solid tumors with reprogrammed T cells can be considered the “next generation” of cancer hallmarks. CAR-T cells fail to be as effective as in liquid tumors for the inability to reach and survive in the microenvironment surrounding the neoplastic foci. The intricate net of cross-interactions occurring between tumor components, stromal and immune cells leads to an ineffective anergic status favoring the evasion from the host’s defenses. Our goal is hereby to trace the road imposed by solid tumors to CAR-T cells, highlighting pitfalls and strategies to be developed and refined to possibly overcome these hurdles. Nature Publishing Group UK 2018-02-15 /pmc/articles/PMC5833816/ /pubmed/29449531 http://dx.doi.org/10.1038/s41419-018-0278-6 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
D’Aloia, Maria Michela
Zizzari, Ilaria Grazia
Sacchetti, Benedetto
Pierelli, Luca
Alimandi, Maurizio
CAR-T cells: the long and winding road to solid tumors
title CAR-T cells: the long and winding road to solid tumors
title_full CAR-T cells: the long and winding road to solid tumors
title_fullStr CAR-T cells: the long and winding road to solid tumors
title_full_unstemmed CAR-T cells: the long and winding road to solid tumors
title_short CAR-T cells: the long and winding road to solid tumors
title_sort car-t cells: the long and winding road to solid tumors
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833816/
https://www.ncbi.nlm.nih.gov/pubmed/29449531
http://dx.doi.org/10.1038/s41419-018-0278-6
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