Fasudil increases temozolomide sensitivity and suppresses temozolomide-resistant glioma growth via inhibiting ROCK2/ABCG2

Resistance to temozolomide (TMZ) is a major clinical challenge in glioma treatment, but the mechanisms of TMZ resistance are poorly understood. Here, we provided evidence that ROCK2 acted redundantly to maintain resistance of TMZ in TMZ-resistant gliomas, and as a ROCK2 phosphorylation inhibitor, fa...

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Detalles Bibliográficos
Autores principales: Zhang, Xin, Liu, Xiuting, Zhou, Wei, Yang, Mengdi, Ding, Yang, Wang, Qing, Hu, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833824/
https://www.ncbi.nlm.nih.gov/pubmed/29416017
http://dx.doi.org/10.1038/s41419-017-0251-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833824/
https://www.ncbi.nlm.nih.gov/pubmed/29416017
http://dx.doi.org/10.1038/s41419-017-0251-9

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