Circular RNA GRB10 as a competitive endogenous RNA regulating nucleus pulposus cells death in degenerative intervertebral disk

Intervertebral disc degeneration (IDD) is an important factor leading to low back pain, but the underlying mechanisms remain poorly understood. Compared with normal nucleus pulposus (NP) tissues, the expression of circ-GRB10 was downregulated in IDD. Furthermore, overexpression of circ-GRB10 inhibit...

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Detalles Bibliográficos
Autores principales: Guo, Wei, Zhang, Bin, Mu, Kun, Feng, Shi-Qing, Dong, Zhan-Yin, Ning, Guang-Zhi, Li, Hao-Ran, Liu, Shen, Zhao, Ling, Li, Yan, Yu, Bing-Bing, Duan, Hui-Quan, Sun, Chao, Li, Yong-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833826/
https://www.ncbi.nlm.nih.gov/pubmed/29476072
http://dx.doi.org/10.1038/s41419-017-0232-z
Descripción
Sumario:Intervertebral disc degeneration (IDD) is an important factor leading to low back pain, but the underlying mechanisms remain poorly understood. Compared with normal nucleus pulposus (NP) tissues, the expression of circ-GRB10 was downregulated in IDD. Furthermore, overexpression of circ-GRB10 inhibited NP cell apoptosis. circ-GRB10 could sequester miR-328-5p, which could potentially lead to the upregulation of target genes related to cell proliferation via the ErbB pathway. In conclusion, the present study revealed that circ-GRB10/miR-328-5p/ERBB2 signaling pathway is involved in IDD development, suggesting that circ-GRB10 might be a novel therapeutic target for IDD.

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