Circular RNA GRB10 as a competitive endogenous RNA regulating nucleus pulposus cells death in degenerative intervertebral disk

Intervertebral disc degeneration (IDD) is an important factor leading to low back pain, but the underlying mechanisms remain poorly understood. Compared with normal nucleus pulposus (NP) tissues, the expression of circ-GRB10 was downregulated in IDD. Furthermore, overexpression of circ-GRB10 inhibit...

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Autores principales: Guo, Wei, Zhang, Bin, Mu, Kun, Feng, Shi-Qing, Dong, Zhan-Yin, Ning, Guang-Zhi, Li, Hao-Ran, Liu, Shen, Zhao, Ling, Li, Yan, Yu, Bing-Bing, Duan, Hui-Quan, Sun, Chao, Li, Yong-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833826/
https://www.ncbi.nlm.nih.gov/pubmed/29476072
http://dx.doi.org/10.1038/s41419-017-0232-z
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author Guo, Wei
Zhang, Bin
Mu, Kun
Feng, Shi-Qing
Dong, Zhan-Yin
Ning, Guang-Zhi
Li, Hao-Ran
Liu, Shen
Zhao, Ling
Li, Yan
Yu, Bing-Bing
Duan, Hui-Quan
Sun, Chao
Li, Yong-Jin
author_facet Guo, Wei
Zhang, Bin
Mu, Kun
Feng, Shi-Qing
Dong, Zhan-Yin
Ning, Guang-Zhi
Li, Hao-Ran
Liu, Shen
Zhao, Ling
Li, Yan
Yu, Bing-Bing
Duan, Hui-Quan
Sun, Chao
Li, Yong-Jin
author_sort Guo, Wei
collection PubMed
description Intervertebral disc degeneration (IDD) is an important factor leading to low back pain, but the underlying mechanisms remain poorly understood. Compared with normal nucleus pulposus (NP) tissues, the expression of circ-GRB10 was downregulated in IDD. Furthermore, overexpression of circ-GRB10 inhibited NP cell apoptosis. circ-GRB10 could sequester miR-328-5p, which could potentially lead to the upregulation of target genes related to cell proliferation via the ErbB pathway. In conclusion, the present study revealed that circ-GRB10/miR-328-5p/ERBB2 signaling pathway is involved in IDD development, suggesting that circ-GRB10 might be a novel therapeutic target for IDD.
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spelling pubmed-58338262018-03-06 Circular RNA GRB10 as a competitive endogenous RNA regulating nucleus pulposus cells death in degenerative intervertebral disk Guo, Wei Zhang, Bin Mu, Kun Feng, Shi-Qing Dong, Zhan-Yin Ning, Guang-Zhi Li, Hao-Ran Liu, Shen Zhao, Ling Li, Yan Yu, Bing-Bing Duan, Hui-Quan Sun, Chao Li, Yong-Jin Cell Death Dis Article Intervertebral disc degeneration (IDD) is an important factor leading to low back pain, but the underlying mechanisms remain poorly understood. Compared with normal nucleus pulposus (NP) tissues, the expression of circ-GRB10 was downregulated in IDD. Furthermore, overexpression of circ-GRB10 inhibited NP cell apoptosis. circ-GRB10 could sequester miR-328-5p, which could potentially lead to the upregulation of target genes related to cell proliferation via the ErbB pathway. In conclusion, the present study revealed that circ-GRB10/miR-328-5p/ERBB2 signaling pathway is involved in IDD development, suggesting that circ-GRB10 might be a novel therapeutic target for IDD. Nature Publishing Group UK 2018-02-23 /pmc/articles/PMC5833826/ /pubmed/29476072 http://dx.doi.org/10.1038/s41419-017-0232-z Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Guo, Wei
Zhang, Bin
Mu, Kun
Feng, Shi-Qing
Dong, Zhan-Yin
Ning, Guang-Zhi
Li, Hao-Ran
Liu, Shen
Zhao, Ling
Li, Yan
Yu, Bing-Bing
Duan, Hui-Quan
Sun, Chao
Li, Yong-Jin
Circular RNA GRB10 as a competitive endogenous RNA regulating nucleus pulposus cells death in degenerative intervertebral disk
title Circular RNA GRB10 as a competitive endogenous RNA regulating nucleus pulposus cells death in degenerative intervertebral disk
title_full Circular RNA GRB10 as a competitive endogenous RNA regulating nucleus pulposus cells death in degenerative intervertebral disk
title_fullStr Circular RNA GRB10 as a competitive endogenous RNA regulating nucleus pulposus cells death in degenerative intervertebral disk
title_full_unstemmed Circular RNA GRB10 as a competitive endogenous RNA regulating nucleus pulposus cells death in degenerative intervertebral disk
title_short Circular RNA GRB10 as a competitive endogenous RNA regulating nucleus pulposus cells death in degenerative intervertebral disk
title_sort circular rna grb10 as a competitive endogenous rna regulating nucleus pulposus cells death in degenerative intervertebral disk
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833826/
https://www.ncbi.nlm.nih.gov/pubmed/29476072
http://dx.doi.org/10.1038/s41419-017-0232-z
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