MYCN drives glutaminolysis in neuroblastoma and confers sensitivity to an ROS augmenting agent

Heightened aerobic glycolysis and glutaminolysis are characteristic metabolic phenotypes in cancer cells. Neuroblastoma (NBL), a devastating pediatric cancer, is featured by frequent genomic amplification of MYCN, a member of the Myc oncogene family that is primarily expressed in the early stage of...

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Detalles Bibliográficos
Autores principales: Wang, Tingting, Liu, Lingling, Chen, Xuyong, Shen, Yuqing, Lian, Gaojian, Shah, Nilay, Davidoff, Andrew M, Yang, Jun, Wang, Ruoning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833827/
https://www.ncbi.nlm.nih.gov/pubmed/29445162
http://dx.doi.org/10.1038/s41419-018-0295-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833827/
https://www.ncbi.nlm.nih.gov/pubmed/29445162
http://dx.doi.org/10.1038/s41419-018-0295-5

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