Temozolomide–perillyl alcohol conjugate downregulates O(6)-methylguanin DNA methltransferase via inducing ubiquitination-dependent proteolysis in non-small cell lung cancer

The DNA repair enzyme O(6)-methylguanin-DNA-methltransferase (MGMT) is able to remove products of alkylating agent such as O(6)-meG and emerges as a central determinant of cancer resistance to temozolomide (TMZ). Temozolomide–perillyl alcohol conjugate (TMZ–POH), a novel TMZ analog developed based o...

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Detalles Bibliográficos
Autores principales: Song, Xingguo, Xie, Li, Chang, Minghui, Geng, Xinran, Wang, Xingwu, Chen, Thomas C., Song, Xianrang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833843/
https://www.ncbi.nlm.nih.gov/pubmed/29426908
http://dx.doi.org/10.1038/s41419-017-0193-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833843/
https://www.ncbi.nlm.nih.gov/pubmed/29426908
http://dx.doi.org/10.1038/s41419-017-0193-2

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