Effects of exercise on sexual function and central mechanism in the streptozotocin-induced diabetic rats

Diabetes mellitus is associated with the impairment of sexual function including desire and orgasmic dysfunction. Sexual dysfunction in the diabetes mellitus is due to a selective defect of the nitric oxide synthase (NOS) within paraventricular nucleus (PVN). c-Fos is an immediate early gene and c-F...

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Autores principales: Lee, Jae-Min, Kim, Tae-Woon, Park, Hye-Sang, Park, Sang-Seo, Shin, Mal-Soon, Sung, Yun-Hee, Seo, Tae-Beom, Kim, Young-Pyo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Exercise Rehabilitation 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833952/
https://www.ncbi.nlm.nih.gov/pubmed/29511647
http://dx.doi.org/10.12965/jer.1836072.036
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author Lee, Jae-Min
Kim, Tae-Woon
Park, Hye-Sang
Park, Sang-Seo
Shin, Mal-Soon
Sung, Yun-Hee
Seo, Tae-Beom
Kim, Young-Pyo
author_facet Lee, Jae-Min
Kim, Tae-Woon
Park, Hye-Sang
Park, Sang-Seo
Shin, Mal-Soon
Sung, Yun-Hee
Seo, Tae-Beom
Kim, Young-Pyo
author_sort Lee, Jae-Min
collection PubMed
description Diabetes mellitus is associated with the impairment of sexual function including desire and orgasmic dysfunction. Sexual dysfunction in the diabetes mellitus is due to a selective defect of the nitric oxide synthase (NOS) within paraventricular nucleus (PVN). c-Fos is an immediate early gene and c-Fos expression represents neuronal activity in response to various stimuli. In the present study, we investigated the effects of treadmill exercise on sexual behaviors and the expressions of NOS and c-Fos in the PVN were evaluated using streptozotocin (STZ)-induced diabetic rats. Diabetes mellitus was induced by intraperitoneal injection of STZ. The rats in the treadmill exercise groups were made to run on a treadmill for 30 min once a day during 4 weeks. Male sexual behaviors were evaluated by recording the number of mounting, intromission, and ejaculation frequency. The present results revealed that treadmill exercise ameliorated sexual dysfunction in the STZ-induced diabetic rats. Treadmill exercise restored the contents of NOS and c-Fos in the PVN. The improving effect of treadmill exercise on sexual function can be considered as the neuronal activating effect of exercise through increasing expressions of NO and c-Fos.
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spelling pubmed-58339522018-03-06 Effects of exercise on sexual function and central mechanism in the streptozotocin-induced diabetic rats Lee, Jae-Min Kim, Tae-Woon Park, Hye-Sang Park, Sang-Seo Shin, Mal-Soon Sung, Yun-Hee Seo, Tae-Beom Kim, Young-Pyo J Exerc Rehabil Original Article Diabetes mellitus is associated with the impairment of sexual function including desire and orgasmic dysfunction. Sexual dysfunction in the diabetes mellitus is due to a selective defect of the nitric oxide synthase (NOS) within paraventricular nucleus (PVN). c-Fos is an immediate early gene and c-Fos expression represents neuronal activity in response to various stimuli. In the present study, we investigated the effects of treadmill exercise on sexual behaviors and the expressions of NOS and c-Fos in the PVN were evaluated using streptozotocin (STZ)-induced diabetic rats. Diabetes mellitus was induced by intraperitoneal injection of STZ. The rats in the treadmill exercise groups were made to run on a treadmill for 30 min once a day during 4 weeks. Male sexual behaviors were evaluated by recording the number of mounting, intromission, and ejaculation frequency. The present results revealed that treadmill exercise ameliorated sexual dysfunction in the STZ-induced diabetic rats. Treadmill exercise restored the contents of NOS and c-Fos in the PVN. The improving effect of treadmill exercise on sexual function can be considered as the neuronal activating effect of exercise through increasing expressions of NO and c-Fos. Korean Society of Exercise Rehabilitation 2018-02-26 /pmc/articles/PMC5833952/ /pubmed/29511647 http://dx.doi.org/10.12965/jer.1836072.036 Text en Copyright © 2018 Korean Society of Exercise Rehabilitation This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lee, Jae-Min
Kim, Tae-Woon
Park, Hye-Sang
Park, Sang-Seo
Shin, Mal-Soon
Sung, Yun-Hee
Seo, Tae-Beom
Kim, Young-Pyo
Effects of exercise on sexual function and central mechanism in the streptozotocin-induced diabetic rats
title Effects of exercise on sexual function and central mechanism in the streptozotocin-induced diabetic rats
title_full Effects of exercise on sexual function and central mechanism in the streptozotocin-induced diabetic rats
title_fullStr Effects of exercise on sexual function and central mechanism in the streptozotocin-induced diabetic rats
title_full_unstemmed Effects of exercise on sexual function and central mechanism in the streptozotocin-induced diabetic rats
title_short Effects of exercise on sexual function and central mechanism in the streptozotocin-induced diabetic rats
title_sort effects of exercise on sexual function and central mechanism in the streptozotocin-induced diabetic rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833952/
https://www.ncbi.nlm.nih.gov/pubmed/29511647
http://dx.doi.org/10.12965/jer.1836072.036
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