Effects of exercise on sexual function and central mechanism in the streptozotocin-induced diabetic rats
Diabetes mellitus is associated with the impairment of sexual function including desire and orgasmic dysfunction. Sexual dysfunction in the diabetes mellitus is due to a selective defect of the nitric oxide synthase (NOS) within paraventricular nucleus (PVN). c-Fos is an immediate early gene and c-F...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Society of Exercise Rehabilitation
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833952/ https://www.ncbi.nlm.nih.gov/pubmed/29511647 http://dx.doi.org/10.12965/jer.1836072.036 |
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author | Lee, Jae-Min Kim, Tae-Woon Park, Hye-Sang Park, Sang-Seo Shin, Mal-Soon Sung, Yun-Hee Seo, Tae-Beom Kim, Young-Pyo |
author_facet | Lee, Jae-Min Kim, Tae-Woon Park, Hye-Sang Park, Sang-Seo Shin, Mal-Soon Sung, Yun-Hee Seo, Tae-Beom Kim, Young-Pyo |
author_sort | Lee, Jae-Min |
collection | PubMed |
description | Diabetes mellitus is associated with the impairment of sexual function including desire and orgasmic dysfunction. Sexual dysfunction in the diabetes mellitus is due to a selective defect of the nitric oxide synthase (NOS) within paraventricular nucleus (PVN). c-Fos is an immediate early gene and c-Fos expression represents neuronal activity in response to various stimuli. In the present study, we investigated the effects of treadmill exercise on sexual behaviors and the expressions of NOS and c-Fos in the PVN were evaluated using streptozotocin (STZ)-induced diabetic rats. Diabetes mellitus was induced by intraperitoneal injection of STZ. The rats in the treadmill exercise groups were made to run on a treadmill for 30 min once a day during 4 weeks. Male sexual behaviors were evaluated by recording the number of mounting, intromission, and ejaculation frequency. The present results revealed that treadmill exercise ameliorated sexual dysfunction in the STZ-induced diabetic rats. Treadmill exercise restored the contents of NOS and c-Fos in the PVN. The improving effect of treadmill exercise on sexual function can be considered as the neuronal activating effect of exercise through increasing expressions of NO and c-Fos. |
format | Online Article Text |
id | pubmed-5833952 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Korean Society of Exercise Rehabilitation |
record_format | MEDLINE/PubMed |
spelling | pubmed-58339522018-03-06 Effects of exercise on sexual function and central mechanism in the streptozotocin-induced diabetic rats Lee, Jae-Min Kim, Tae-Woon Park, Hye-Sang Park, Sang-Seo Shin, Mal-Soon Sung, Yun-Hee Seo, Tae-Beom Kim, Young-Pyo J Exerc Rehabil Original Article Diabetes mellitus is associated with the impairment of sexual function including desire and orgasmic dysfunction. Sexual dysfunction in the diabetes mellitus is due to a selective defect of the nitric oxide synthase (NOS) within paraventricular nucleus (PVN). c-Fos is an immediate early gene and c-Fos expression represents neuronal activity in response to various stimuli. In the present study, we investigated the effects of treadmill exercise on sexual behaviors and the expressions of NOS and c-Fos in the PVN were evaluated using streptozotocin (STZ)-induced diabetic rats. Diabetes mellitus was induced by intraperitoneal injection of STZ. The rats in the treadmill exercise groups were made to run on a treadmill for 30 min once a day during 4 weeks. Male sexual behaviors were evaluated by recording the number of mounting, intromission, and ejaculation frequency. The present results revealed that treadmill exercise ameliorated sexual dysfunction in the STZ-induced diabetic rats. Treadmill exercise restored the contents of NOS and c-Fos in the PVN. The improving effect of treadmill exercise on sexual function can be considered as the neuronal activating effect of exercise through increasing expressions of NO and c-Fos. Korean Society of Exercise Rehabilitation 2018-02-26 /pmc/articles/PMC5833952/ /pubmed/29511647 http://dx.doi.org/10.12965/jer.1836072.036 Text en Copyright © 2018 Korean Society of Exercise Rehabilitation This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Lee, Jae-Min Kim, Tae-Woon Park, Hye-Sang Park, Sang-Seo Shin, Mal-Soon Sung, Yun-Hee Seo, Tae-Beom Kim, Young-Pyo Effects of exercise on sexual function and central mechanism in the streptozotocin-induced diabetic rats |
title | Effects of exercise on sexual function and central mechanism in the streptozotocin-induced diabetic rats |
title_full | Effects of exercise on sexual function and central mechanism in the streptozotocin-induced diabetic rats |
title_fullStr | Effects of exercise on sexual function and central mechanism in the streptozotocin-induced diabetic rats |
title_full_unstemmed | Effects of exercise on sexual function and central mechanism in the streptozotocin-induced diabetic rats |
title_short | Effects of exercise on sexual function and central mechanism in the streptozotocin-induced diabetic rats |
title_sort | effects of exercise on sexual function and central mechanism in the streptozotocin-induced diabetic rats |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833952/ https://www.ncbi.nlm.nih.gov/pubmed/29511647 http://dx.doi.org/10.12965/jer.1836072.036 |
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