Allele-specific long-distance regulation dictates IL-32 isoform switching and mediates susceptibility to HIV-1

We integrated data obtained from HIV-1 genome-wide association studies with T cell–derived epigenome data and found that the noncoding intergenic variant rs4349147, which is statistically associated with HIV-1 acquisition, is located in a CD4(+) T cell–specific deoxyribonuclease I hypersensitive reg...

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Detalles Bibliográficos
Autores principales: Palstra, Robert-Jan, de Crignis, Elisa, Röling, Michael D., van Staveren, Thomas, Kan, Tsung Wai, van Ijcken, Wilfred, Mueller, Yvonne M., Katsikis, Peter D., Mahmoudi, Tokameh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833994/
https://www.ncbi.nlm.nih.gov/pubmed/29507875
http://dx.doi.org/10.1126/sciadv.1701729

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833994/
https://www.ncbi.nlm.nih.gov/pubmed/29507875
http://dx.doi.org/10.1126/sciadv.1701729

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