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Sensitization of multidrug-resistant cancer cells to Hsp90 inhibitors by NSAIDs-induced apoptotic and autophagic cell death

NSAIDs (non-steroidal anti-inflammatory drugs) have potential use as anticancer agents, either alone or in combination with other cancer therapies. We found that NSAIDs including celecoxib (CCB) and ibuprofen (IBU) significantly potentiated the cytotoxicity of Hsp90 inhibitors in human multidrug-res...

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Detalles Bibliográficos
Autores principales: Moon, Hyun-Jung, Kim, Hak-Bong, Lee, Su-Hoon, Jeun, So-Eun, Kang, Chi-Dug, Kim, Sun-Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834263/
https://www.ncbi.nlm.nih.gov/pubmed/29541415
http://dx.doi.org/10.18632/oncotarget.24130