Structural Insights into the Mechanisms of Action of Short-Peptide HIV-1 Fusion Inhibitors Targeting the Gp41 Pocket

The deep hydrophobic pocket of HIV-1 gp41 has been considered a drug target, but short-peptides targeting this site usually lack potent antiviral activity. By applying the M-T hook structure, we previously generated highly potent short-peptide fusion inhibitors that specifically targeted the pocket...

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Detalles Bibliográficos
Autores principales: Zhang, Xiujuan, Zhu, Yuanmei, Hu, Hao, Zhang, Senyan, Wang, Pengfei, Chong, Huihui, He, Jinsheng, Wang, Xinquan, He, Yuxian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834435/
https://www.ncbi.nlm.nih.gov/pubmed/29535974
http://dx.doi.org/10.3389/fcimb.2018.00051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834435/
https://www.ncbi.nlm.nih.gov/pubmed/29535974
http://dx.doi.org/10.3389/fcimb.2018.00051

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