Sipa1 deficiency unleashes a host-immune mechanism eradicating chronic myelogenous leukemia-initiating cells

Chronic myelogenous leukemia (CML) caused by hematopoietic stem cells expressing the Bcr-Abl fusion gene may be controlled by Bcr-Abl tyrosine kinase inhibitors (TKIs). However, CML-initiating cells are resistant to TKIs and may persist as minimal residual disease. We demonstrate that mice deficient...

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Detalles Bibliográficos
Autores principales: Xu, Yan, Ikeda, Satoshi, Sumida, Kentaro, Yamamoto, Ryusuke, Tanaka, Hiroki, Minato, Nagahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834470/
https://www.ncbi.nlm.nih.gov/pubmed/29500416
http://dx.doi.org/10.1038/s41467-018-03307-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834470/
https://www.ncbi.nlm.nih.gov/pubmed/29500416
http://dx.doi.org/10.1038/s41467-018-03307-8

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