Metformin-induced caveolin-1 expression promotes T-DM1 drug efficacy in breast cancer cells

Trastuzumab emtansine (T-DM1) is an antibody drug conjugate (ADC) that was recently approved for the treatment of HER-2-positive metastatic breast cancer. The drug sensitivity of ADCs depends mainly on the internalization efficiency of the drug. Caveolin-1 was shown to promote T-DM1 internalization...

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Detalles Bibliográficos
Autores principales: Chung, Yuan-Chiang, Chang, Ching-Ming, Wei, Wan-Chen, Chang, Ting-Wei, Chang, King-Jen, Chao, Wei-Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834501/
https://www.ncbi.nlm.nih.gov/pubmed/29500444
http://dx.doi.org/10.1038/s41598-018-22250-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834501/
https://www.ncbi.nlm.nih.gov/pubmed/29500444
http://dx.doi.org/10.1038/s41598-018-22250-8

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