Assessing the Heterogeneity of the Fc-Glycan of a Therapeutic Antibody Using an engineered FcγReceptor IIIa-Immobilized Column

The N-glycan moiety of IgG-Fc has a significant impact on multifaceted properties of antibodies such as in their effector function, structure, and stability. Numerous studies have been devoted to understanding its biological effect since the exact composition of the Fc N-glycan modulates the magnitu...

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Detalles Bibliográficos
Autores principales: Kiyoshi, Masato, Caaveiro, Jose M. M., Tada, Minoru, Tamura, Hiroko, Tanaka, Toru, Terao, Yosuke, Morante, Koldo, Harazono, Akira, Hashii, Noritaka, Shibata, Hiroko, Kuroda, Daisuke, Nagatoishi, Satoru, Oe, Seigo, Ide, Teruhiko, Tsumoto, Kouhei, Ishii-Watabe, Akiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834517/
https://www.ncbi.nlm.nih.gov/pubmed/29500371
http://dx.doi.org/10.1038/s41598-018-22199-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834517/
https://www.ncbi.nlm.nih.gov/pubmed/29500371
http://dx.doi.org/10.1038/s41598-018-22199-8

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